There is just one scheduled primetime game inside Lucas Oil Stadium for the upcoming 2025 NFL regular season. The Indianapolis Colts will host the San Francisco 49ers on Dec. 22 to close Week 16 on Monday Night Football.
December’s slugfest may be viewed as an interesting chess match dueled between two brilliant minds in 49ers ninth-year head coach Kyle Shanahan against Colts head coach Shane Steichen. Both coaches can orchestrate clever play designs to create explosive offensive plays. Despite missing out on the playoffs, the 49ers produced the fourth-most total yards (6,397) of any offense in 2024.