The Indianapolis Colts suffered a number of injuries in training camp and the preseason, and some of those players, such as rookie cornerback Justin Walley, were never going to be ready for Week 1. They were lost for the season.
Still, most of the key players for Indianapolis were good to go, and Week 1 against the Miami Dolphins is no different. Indy's offense should run with efficiency, as long as quarterback Daniel Jones is decent, and the Colts' defense should get pressure on Miami quarterback Tua Tagovailoa.
Sure, Indianapolis hasn't won an opener in 11 years, and Miami could easily make that 12, but it appears injuries won't be the cause for a loss (not to jinx anything, of course).