Yes, it’s May. Yes, the 2025 NFL season doesn’t kick off for the Indianapolis Colts until September 7th, but that doesn’t mean we can’t take a look ahead at the opening day matchup with the Miami Dolphins. Opening odds is back, and FanDuel Sportsbook is giving fans something to look forward to by making week one just a little bit more of a reality. Who knows how much the spread will move between now and September, but the current opening odds favor the Colts from Lucas Oil Stadium at 1.5-points.
The money line sits at -116 with the over/under coming in at 45.