The Indianapolis Colts have the opportunity to start the 2025 NFL season with an impressive 5-1 record. To do that and stay atop the AFC, the Colts will have to beat the Arizona Cardinals in Week 6. The Cardinals have lost three straight games, but they still have enough talent to give Indianapolis problems.
The Arizona player to watch is no stranger to the Colts. The Cardinals’ No. 1 wide receiver Marvin Harrison Jr. is the son of Indianapolis legend and Pro Football Hall of Famer Marvin Harrison Sr.
Now, Harrison Jr. will face his father’s former team for the first time in his career, and the game just happens to be in Indianapolis too.