Senior receiver Darrius Shepherd ripped off huge chunks of yardage on both receptions and punt returns, and the No. 1-ranked Bison cast aside the No. 7-ranked Redbirds for a 28-14 victory before a crowd of 18,553.
The defending national champion Bison won their 13th consecutive game and improved to 7-0 overall and 4-0 in the Missouri Valley Football Conference. ISU slipped to 5-2 and 2-2, respectively.
ISU's best chance for first-half points evaporated when quarterback Brady Davis was intercepted by safety Robbie Grimsley on third-and-goal at the Bison 4 in the second quarter.
NDSU hurt the Redbirds deep with Shepherd, who caught five passes for 122 yards in the opening half.