ISU, which finished with a 19-14 record, was making its fourth straight NCAA appearance. Freshman Aliyah Moore paced the Redbirds, who had a .127 hitting percentage, with nine kills while sophomore Tamara Otene added eight.
Seniors Caitlyn Newton and Grace Cleveland, a Normal Community High School graduate, paced the Boilermakers (24-6) with 12 and nine kills, respectively. Cleveland had two of Purdue's eight blocks.
The Boilermakers advanced to Saturday's second round against Dayton (26-5), which eliminated Marquette in four sets.
ISU hung with the Boilermakers in the first set. Two kills from Sarah Kushner forged a 19-all tie before Purdue pulled away.