Catarina Macario scored two goals and the United States defeated Italy 3-0 on Friday night in a friendly match at Orlando's Inter&Co Stadium.
It was the first of two friendlies between the teams, with the second scheduled for Monday in Fort Lauderdale.
Olivia Moultrie also scored while goalkeeper Claudia Dickey earned the shutout in just her fifth appearance at the senior level.
"I think obviously we wanted to keep building on the performances we had last camp, and the emphasis on coming out strong and sticking to our principles, and I think that's what we did," said U.