Victory for Hull City on Saturday (15:00 BST) will assure them of Championship football next season, while a win for Derby could move them within sight of another campaign of second-tier football.
Hull City have won just one of their past 11 league games against Derby (D2 L8), beating them 2-0 in October 2019.
Derby have alternated between winning (five) and not winning (D1 L3) in their past nine away games against Hull, beating them 1-0 on their last visit in August 2021.
Hull won their last league game against Preston, but only once this season have the Tigers won consecutive league games (three in a row in September-October).