Greg Docherty’s first Hull City goal rescued a point at Oxford in front of 1,000 fans at the Kassam Stadium.
James Henry’s 10th-minute strike put the U’s in front but the Tigers hit back midway through the second period when Docherty volleyed home.
A first draw of the campaign leaves Hull City two points clear at the top of League One.
Grant McCann named an unchanged team for Hull City’s first trip to Oxford in 17 years.
The Tigers were playing in front of a crowd for the first time in 273 days, with 1,000 socially-distanced U’s fans in attendance at the three-sided Kassam Stadium.