Manchester meets Merseyside this weekend, headlined by Manchester United vs. Liverpool.
Prior to Sunday's huge clash at Old Trafford, Manchester City travel to Everton looking to keep the heat on leaders Chelsea, who will be hoping to bounce back after a 2-0 defeat at Tottenham ended their winning run.
Antonio Conte's side travel to champions Leicester on Saturday evening and elsewhere, Arsenal are at Swansea and there's a big game at the bottom as Sam Allardyce takes Crystal Palace to former club West Ham.
Predict the outcome of all the matches in our match polls.
MAN UNITED: If United beat Liverpool they'll have won 10 games in a row, which shows the huge turnaround from a few months ago when they couldn't stop drawing.