Hull City suffered back-to-back defeats for the first time this season after losing a five-goal contest with Blackpool.
Birthday boy Mallik Wilks put the Tigers in front but Jerry Yates levelled on the stroke of half-time.
Keshi Anderson powered Pool ahead and although Reece Burke’s header looked to have rescued a point, CJ Hamilton struck a winner in added time.
Grant McCann freshened up his side for the trip to Bloomfield Road, making four changes from the surprise home defeat to Shrewsbury.
In came Lewie Coyle, Regan Slater, James Scott and Tom Eaves, with Josh Emmanuel, Hakeeb Adelakun and Josh Magennis dropping to the bench and George Honeyman missing out completely.