Greg Docherty's superb strike inspired struggling Hull to their first Championship away win of the season at Blackpool.
Dimitrios Pelkas' corner took a touch off Ryan Longman and crept in to give Hull the lead before Kenny Dougall levelled with a neat back-post finish.
Docherty rifled the Tigers back in front with a stunning 25-yard shot which found the top corner on the stroke of half-time.
Regan Slater's powerful strike also found the top corner, albeit via a big deflection, to seal a first win for Hull over the Tangerines since 2004.
A second win for interim manager Andy Dawson in his five-match tenure lifts the Tigers to 19th, three points above the relegation places, while Blackpool drop below them to 21st after a seventh defeat of the campaign.