The former went deep, 48 yards deep, to the latter for a touchdown at the 12:09 mark of the fourth quarter.
Watson danced out of some trouble in the pocket, righted himself, and went up the right side to Fuller for the score. A Ka'imi Fairbairn extra point pulled the Texans to within 26-20.
It was the second straight game for Fuller to catch two touchdowns, and it was his fourth score of the season. For Watson, it was the fifth straight game with a touchdown pass or run. He also set a Texans rookie record with his 10th touchdown pass in a season.