Texans president Jamey Rootes - who has been with the team since 2001, a year before the franchise played its first game - resigned Wednesday.
The Houston Chronicle's John McClain was first to report the news.
The 54-year-old Rootes oversaw the business and administrative side for the Texans, helping the franchise sell out every game at NRG Stadium before COVID-19 forced the team to limit ticket sales last season. Under Rootes' guidance, the Texans are valued at $3.3 billion, according to Forbes, making them the 10th-most valuable franchise in the NFL.
The team's senior vice president of corporate development Greg Grissom, who has been with the franchise since 2002, will take over Rootes' duties until a new president is hired, according to McClain.