Justin Reid suffered a concussion against Baltimore and is not expected to play on Thursday vs. Indianapolis.
Texans coach Bill O'Brien said any player who suffered a concussion in Sunday's game against Baltimore would be unlikely to play against the Colts on Thursday.
That means safeties Justin Reid and Mike Adams will likely miss the game.
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O'Brien described cornerback Bradley Roby and wide receiver Will Fuller as game-time decisions again due to strained hamstrings.
O'Brien said he hasn't ruled out the possibility that rookie cornerback Lonnie Johnson Jr.