The Week 1 NFL schedule for the 2025 season brings some exciting matchups. The Lions take a trip to Lambeau Field, the 49ers and Seahawks face off in an NFC West showdown, and a must-see QB duel between Lamar Jackson and Josh Allen will be held in Buffalo.
We have you covered with everything you need to know. Our NFL Nation reporters take you inside the locker room with the best thing they heard this week, and ESPN Research provides a key stat to know and a betting nugget for each contest.