The Pro Bowl wide receiver caught 11 passes for 149 yards in the 26-16 loss to the 49ers, pulling in touchdown passes late in the second quarter and early in the third.
"I wish we could've got it to him more," head coach Bill O'Brien said. "San Francisco did a good job of doubling him a lot, especially after the second touchdown catch. They really traveled two guys with him quite a bit and it was difficult."
Hopkins caught a 7-yard strike from T.J. Yates with 0:54 remaining in the first half, and it was one of four recpeptions on the drive.