The Houston Texans enter 2025 as even-money favorites to win their third straight AFC South crown.
Not far behind them are the Jacksonville Jaguars (+300), who went 4-13 last season but added dynamic two-way playmaker Travis Hunter in the draft, and the Indianapolis Colts (+350).
The Tennessee Titans have the worst odds to win the division at +750, but rookie QB Cam Ward is among Rookie of the Year favorites, giving them hope coming off a three-win season.
How will things play out this season?