The No. 20 Cougars are right in the middle of a tough three games in a six-day stretch and will face the Bulls in Tampa, Florida on Wednesday night.
Junior guard DeJon Jarreau had 12 points and six assists and junior Fabian White Jr. had 11 points in the win. Caleb Mills also had 11 points.
South Florida enters the game winners of its last three, including a win against Memphis in its latest contest.