The last time the Astros faced off against the Pirates was back in 2019, from June 25 through 27. Houston won the opener by a 5-1 margin before dropping the final two by scores of 14-2 and 10-0. Their lone win of the series featured home runs by Yuli Gurriel (7) and Alex Bregman (22). Gerrit Cole, who began his career with the Bucs, gave up one run over six innings of work to earn the win.
Houston opened the season with a split against the White Sox at home and a two-to-one series loss to the Detroit Tigers.