Gametime and Starting Pitchers (subject to change)
Monday at 7:10 PM CT — Noah Syndergaard (1-4, 7.16) vs. J.P. France (6-3, 2.87)
Tuesday at 7:10 PM CT — Gavin Williams (1-2, 3.35) vs. Framber Valdez (8-7, 3.29)
Wednesday at 1:10 PM CT — Tanner Bible (7-2, 3.11) vs. Cristian Javier (7-2, 4.33)
All-Time Head-to-Head
Houston is 39-44 in all-time regular season play against the Guardians. The resulting .470 winning percentage is their fourth-worst against an American League team. The playoffs are a different story, with the Astros sweeping the then-Indians in the 2018 ALDS in three games.