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Take 5: Seahawks in trouble vs. 49ers?

NFL: Arizona Cardinals at Seattle Seahawks

Normally, the Seattle Seahawks should have the upper hand in Week 17's biggest matchup, a rematch with the San Francisco 49ers.

They won the first encounter in Santa Clara, Calif., and now will benefit from the raucous home crowd at CenturyLink Field in prime time.

And yet, there are many reasons to think Sunday's game won't play out like the first meeting between the NFC West rivals.

1. Injuries undermining Seahawks' offensive identity

On many teams, losing your top three running backs would lead to a shift in offensive identity, toward a pass-heavy approach.