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NFL against the spread picks: 49ers and Saints both need this big game

Nobody will have a tougher eight-day stretch this NFL season than the San Francisco 49ers.

First up was a trip to the East Coast and an early start against the Baltimore Ravens. In a physical, entertaining game, the 49ers lost on a field goal on the final play.

The reward for that tough loss is a trip to the Superdome to face the 10-2 New Orleans Saints. There’s no time to rest in the NFL.

Here is what’s at stake for the 49ers: Win and they’ll be 11-2 and still in line to be the No.