The NFL returns with 32 teams again vying for a place in Super Bowl LIX at the Superdome in New Orleans.
The Kansas City Chiefs, led by Patrick Mahomes and Travis Kelce, go in search of an unprecedented third consecutive Lombardi Trophy after retaining their crown in Las Vegas earlier this year.
After their near miss, the San Francisco 49ers could again contend, while the Detroit Lions, Green Bay Packers and Houston Texans are among a clutch of teams on the rise.
But a long season contested over 18 weeks will see plenty of twists and turns before the play-offs even begin.