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Green Bay Packers at San Francisco 49ers odds, picks and prediction

The Green Bay Packers (5-2) visit the injury-ravaged San Francisco 49ers (4-4) at Levi's Stadium for Thursday Night Football in Week 9. Kickoff will be at 8:20 p.m. ET. Below, we preview the Packers-49ers betting odds and lines and make our NFL picks and predictions.

Packers at 49ers betting odds and lines

  • Money line : Packers -250 (bet $250, win $100) | 49ers +200 (bet $100, win $200)
  • Against the spread/ATS : Packers -5.5 (-110) | 49ers +5.5 (-110)
  • Over/Under : 49.