The Detroit Lions opened as slight betting favorites for their Week 1 matchup with the Green Bay Packers when it was first announced back in May.
But in the week building up to the start of the 2025 NFL season, the Packers acquired All-Pro edge rusher Micah Parsons and the odds have flipped toward the home team.
The Lions are now 2.5-point underdogs in their season opener, according to odds from FanDuel, DraftKings and BetMGM.
This is the largest point spread against the Lions since Week 17 of the 2023 season, according to SB Nation.