The NFL International Series continues in Week 1 of the 2025 season, with the Kansas City Chiefs taking on the Los Angeles Chargers in a renewal of this AFC West rivalry from São Paulo, Brazil. This marks the second regular-season game to take place in South America, following last year's game between the Philadelphia Eagles and the Green Bay Packers.
Kansas City is coming off its third consecutive trip to the Super Bowl after failing to three-peat against the Eagles in SBLIX. Patrick Mahomes and company look to bounce back minus wide receiver Rashee Rice, who will serve a six-game suspension, and All-Pro guard Joe Thuney, who was traded to Chicago in the offseason.