There are a few ways that this San Francisco 49ers' offense can create issues for the Green Bay Packers' defense--specifically with their ability to run the ball and pick up yards after the catch.
Of course, it's going to take a group effort to try to contain Elijah Mitchell, Deebo Samuel, George Kittle, and the rest of the Niner playmakers, but the Packers' safeties are going to play a particularly important role in doing so.
We will see if Joe Barry switches things up against the run-heavy Niners, but typically, he will play with lightboxes, and it's important for both Adrian Amos and Darnell Savage to be active in the run game.