There is no bigger regular season game possible than 1 vs 2. If all goes well, Gonzaga could have multiple 1 vs 2 games in the matter of two weeks. First they must take care of business against the Baylor Bears, a team they are 5-0 against all-time.
Baylor, not Gonzaga, had the most number one votes in the preseason AP Poll. The majority of those switched over to the Zags after they throttled Kansas, but after the first 10 days of the season, it seems very clear that Gonzaga and Baylor are a tier ahead of every other team currently.