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ESPN.com · Nov 27, 2025

2025 NFL Thanksgiving schedule, picks, odds, injuries

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The Week 13 schedule for the 2025 NFL season begins with a great slate of Thanksgiving Day matchups, and we have you covered for what should be an exciting holiday. According to ESPN Research, the average over/under point total of 51.2 is the highest for Thanksgiving games over the past 40 seasons. Buckle up.

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