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Gameday Central: Florida State Seminoles vs. Louisville Cardinals

The Florida State Seminoles (2-0) travel to Louisville to start their 2022 ACC football season against the one loss Louisville Cardinals on Friday night, under the lights, as the nation watches on ESPN.

With a 7:30pm kickoff from Cardinal Stadium in Derby City, Louisville is 1-1 after dropping the season opener at Syracuse 31-7, and beating UCF last week 20-14. It is the Cardinals’ first home game of the year. FSU is 16-6 all-time against the Cardinals, including a 6-3 mark away from Tallahassee.

According to DraftKings, Florida State is a 2.