Troy Brouwer, Mike Hoffman and Denis Malgin also scored for the Panthers, who won their third straight. Roberto Luongo made 29 saves for his third straight win after missing nearly a month with a knee injury.
Brock Nelson and Mathew Barzal scored goals for New York, which has lost three in a row after winning its previous five. Robin Lehner stopped 27 shots.
Brouwer recorded an empty-net goal with less than a second remaining.
The Panthers went ahead 3-2 on a 4-on-3 power play at 4:43 of the third period whAleksander Barkov scored the go-ahead goal in the third period, and the Florida Panthers beat the New York Islanders 4-2 on Saturday night.