Like offenses in Week 1 trying to click after a few exhibitions, fantasy football owners have rust of their own to shake off in the opening week.
Unlike those offenses, owners don't have a good way to prep for the tough start/sit decisions ahead, as draft prep is a different animal compared to actual lineup decisions. The mentioned potential offensive struggles of NFL teams trying to get on the same page only makes the task facing owners even more difficult.
The eventual winning owners in Week 1 use a combination of last year's data and projections—with a dash of luck—to pick up a win.