Fantasy football players had an entire summer to prepare for their drafts, but the critical lineup decisions start in Week 1.
After all, those late-round sleepers and early-round playmakers won't be worth much on your bench in lieu of the wrong starters. With that in mind, here is some lineup guidance for Week 1 and a breakdown of the top players at each position.
The rankings were determined for standard-scoring leagues using a combination of overall talent and matchups and will almost certainly change on a week-to-week basis throughout the year.
Quarterbacks
Top Week 1 Quarterbacks
| Rank | Player | Opponent |
| 1 | Russell Wilson, Seattle Seahawks | Miami Dolphins |
| 2 | Andrew Luck, Indianapolis Colts | Detroit Lions |
| 3 | Aaron Rodgers, Green Bay Packers | Jacksonville Jaguars |
| 4 | Drew Brees, New Orleans Saints | Oakland Raiders |
| 5 | Eli Manning, New York Giants | Dallas Cowboys |
| 6 | Blake Bortles, Jacksonville Jaguars | Green Bay Packers |
| 7 | Cam Newton, Carolina Panthers | Denver Broncos |
| 8 | Derek Carr, Oakland Raiders | New Orleans Saints |
| 9 | Ben Roethlisberger, Pittsburgh Steelers | Washington |
| 10 | Kirk Cousins, Washington | Pittsburgh Steelers |
Russell Wilson is my personal pick for league MVP this year, and he has the opportunity to start his season against a Miami Dolphins team that finished a middling 19th in the NFL in scoring defense in 2015.