For the most part, setting your fantasy football lineup for Week 1 of the NFL season is the easiest time of the year. After all, the majority of players are healthy and most of the projections haven't changed since you took these players in your draft.
Make sure no late injury news develops, give a final spin through your roster and you should be set.
But maybe you're weak at a position or two. Or you missed out on some of your potential draft targets and are entering the season planning to stream a position, knowing you're going to have to be busy on the waiver wire on a weekly basis to find a player or two to plug into your lineup.