In fantasy, volume is king. That is no different in PPR leagues, except that receiving work ascends in importance. For Week 1, defenses and player roles are incredibly hard to predict, particularly following an offseason without any preseason matches, so player talent should trump matchups in projections.
All week, fantasy managers will need to monitor injuries and team updates, as the murmurs from training camps begin to solidify through official channels. Right now, a variety of official and unofficial depth charts are flowing across the fantasy media world, but those have to be taken with a grain of salt as history has proved that they can be unreliable.