Yerry Mina will make his full Everton debut at Chelsea, as Marco Silva makes one change from the team which has started the Blues' past three matches.
Centre-half Mina, who played the closing minutes of last week's victory over Brighton & Hove Albion and featured from start to finish in the midweek friendly with Gor Mahia, comes in for Kurt Zouma, who is ineligible for the fixture with his parent club.
The Colombian will be partnered in the middle of defence by Michael Keane, recalled this week by England, with Lucas Digne and Seamus Coleman occupying the Toffees' full-back spots.