Ramiro Funes Mori picked up his 14th cap for Argentina in their overnight 1-0 victory against Uruguay.
Lionel Messi marked his return from a short-lived international retirement with the only goal of the game to see La Albiceleste leapfrog their opponents to the top of their World Cup qualification group.
The clean sheet for Funes Mori and Co was all the more impressive given they played the entire second half with 10 men following a second yellow card for forward Paulo Dybala.
Elsewhere in South America, new Blues signing Enner Valencia played the full 90 minutes for Ecuador but was unable to prevent a 3-0 defeat to Brazil.