Everton were left counting the cost of another injury during the international break after Argentina defender Ramiro Funes Mori was carried off.
The centre-back was shown holding his left knee as he left the pitch after only 36 minutes of Argentina's 2-0 defeat by Bolivia on Tuesday evening.
The Toffees have already seen Seamus Coleman sidelined until next season with a horrific leg break suffered during the Republic of Ireland's draw with Wales last Friday.
Midfielder James McCarthy, meanwhile, did not even make it to kick-off in Dublin after aggravating a hamstring problem in the warm-up.