It's the Merseyside derby and you can hear exclusive national radio coverage of the match right here.
Liverpool may have beaten Manchester City in the first leg of their Champions League quarter-final but they will need to refocus as they take on their local foes.
Mohamed Salah is ruled out completely and doesn't make the bench for Liverpool, while Dominic Solanke and Danny Ings start.
Meanwhile, for Everton Idrissa Gueye is only fit enought to make the bench.
Confirmed team news
Everton XI:Pickford, Coleman, Jagielka, Keane, Baines, Rooney, Schneiderlin, Walcott, Davies, Bolasie, Tosun.