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Fansided · Nov 1, 2025

Duke at Clemson: Final betting odds and predictions for the Blue Devils' must-win matchup

Duke v California | Thearon W. Henderson/GettyImagesThe Duke football program enters a must-win scenario coming off the bye, as it heads to Death Valley to take on Clemson. After a major missed opportunity at home against No. 8 Georgia Tech, where Duke fell 27-18, the Blue Devils absolutely need to stack a win this week to remain in contention for an ACC Championship. Now 4-3 overall and 3-1 in conference play, Duke most likely will have to win out to have any hope of bringing the first ACC crown to Durham since 1989. However, that starts on Saturday with a road win over Clemson, which has been potentially the biggest disappointment in college football this season. Here are the final betting odds with a prediction before the Blue Devils kick it off against the Tigers at 12:00 pm EST.

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