Mikie Mahtook pinch-ran and replaced Upton in left field.
The Tigers, having played 11 games in 10 days this trip, already have enough injury troubles with second baseman Ian Kinsler and catcher James McCann on the 10-day disabled list. Another outfielder, Jim Adduci, has been on the 10-day DL for the last couple of weeks with an oblique strain, further depleting their depth.
The Tigers are off Thursday before opening a six-game homestand Friday against the White Sox.
Jason Beck has covered the Tigers for MLB.