The Tigers went down 1-2-3 in the bottom of the sixth inning, for the second inning in a row and the third time in the game.
Miguel Cabrera grounded out to shortstop before Victor Martinez flew out to Robbie Grossman in foul territory and J.D. Martinez struck out swinging.
The Tigers have a run and three hits through six, and trail 7-1 going to the top of the seventh.
Twins leave runners at corners in 6th
Tigers reliever Buck Farmer stranded runners at the corners in the top of the sixth inning.
With one out, Logan Schafer tripled to the gap.