Nick Castellanos belted a two-run homer to left field off Indians starter Danny Salazar to tie the game 3-3 in the top of the sixth.
Victor Martinez singled with one out.
Miguel Cabrera flied out to the warning track to start the inning.
Bot 5: Indians add run
The damage was minimized yet again by Tigers pitchers. This time, reliever Alex Wilson struck out back-to-back batters to limit the Indians to one run in the fifth inning.
Cleveland leads 3-1 after five innings.
Tigers reliever Dustin Molleken gave up back-to-back singles (Rajai Davis, Jason Kipnis) and was pulled.