Chicago White Sox manager Tony La Russa removed right-hander Michael Kopech from his start after the sixth inning with a no-hitter intact.
The 26-year-old was in complete control.
Kopech, in his 21st start this season, was replaced by righty reliever Reynaldo Lopez for the seventh inning. The first batter Lopez faced, Javier Báez, laced a single into right field to spoil the chance at a combined no-hitter.
The Detroit Tigers lost, 2-0, in the first of three games against the White Sox at Guaranteed Rate Field, as righty reliever Alex Lange gave up two runs on three singles, one walk and one hit-by-pitch in the bottom of the seventh.