Week 5 of the 2022 NFL season kicks off with the Peyton Manning Bowl, as the Indianapolis Colts (+3.5)
(1-2-1) travel to Colorado to take on the Denver Broncos (-3.5) (2-2).
The Colts are a bit of a conundrum this season. They tied the Houston Texans (+7)
—the only winless team in the NFL—in the opener, then got shut out by the Jacksonville Jaguars (-7) in Week 2. They upset the Kansas City Chiefs (-7) in Week 3, then fell to the Tennessee Titans (-1.5) in Week 4, despite quarterback Matt Ryan throwing for 356 yards and two touchdowns.