In the categoy of "life comes at you fast", Detroit Lions tight end Sam LaPorta went from out for a game, to on IR to most likely out for the season due to a back injury in the span of a week.
It's impossible to overstate LaPorta's importance to the Lions' offense. His absence means others (Jameson Williams, Amon-Ra St. Brown, Jahmyr Gibbs) are in line for targets from Jared Goff, but his being out also marked a serious shift in the Lions' offensive personnel deployment in Week 11 against the Philadelphia Eagles.