The Philadelphia Eagles and Detroit Lions face off in an NFL Week 1 game on Sunday, Sept. 11.
The Eagles are a 3.5-point favorite, according to Tipico Sportsbook.
Philadelphia is -200 on the money line in the game, which will be played at Ford Field in Detroit.
The Lions are +160.
The over/under for the game is set at 48.5 points.
The Eagles went 9-8 in the regular season in 2021. They lost in the NFC Wild Card round.
The Lions went 3-13-1 last season.
More:Super Bowl 57 odds: Preseason betting odds for every NFL team to win 2022-2023 Super Bowl
The Eagles beat the Lions last season at Ford Field on Oct.