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Buffalo Bills vs. Los Angeles Rams staff picks, predictions for ‘Thursday Night Football’

Meaningful NFL games are officially back!

The 2022 regular season kicks off with a bang on “Thursday Night Football.” The opening game features the defending Super Bowl Champion Los Angeles Rams (+2.5)

hosting the Buffalo Bills (-2.5). The Bills were seemingly a coin toss away from this being the matchup we would have seen last February, so the schedule planners were smart to get this game on the docket early in the season.

The Rams have won their last five season openers—the longest streak amongst NFC teams—but as the defending champs, they’ll have a much bigger target on their backs this season.