So there were quite a number of significant changes this week, but that seems to be the new normal with all of the injuries to this team.
The game-day inactives were as follows: QB 3 Drew Lock, RB 30 Phillip Lindsay, CB 27 Devontae Harris, G 52 Netane Muti, QB 5 Blake Bortles, TE 85 Albert Okwuegbunam, and OLB 97 Jeremiah Attaochu.
Offense
| Player | Position | game 1 | game 2 | game 3 | game 4 |
| Lloyd Cushenberry III | C | 100% | 100% | 100% | 100% |
| Dalton Risner | G | 100% | 100% | 100% | 100% |
| Graham Glasgow | G | 100% | 100% | 100% | 100% |
| Elijah Wilkinson | T | 100% | 100% | 100% | 0% |
| Garett Bolles | T | 100% | 100% | 100% | 100% |
| KJ Hamler | WR | 0% | 62% | 92% | 20% |
| Noah Fant | TE | 73% | 79% | 84% | 50% |
| Tim Patrick | WR | 85% | 65% | 84% | 76% |
| Jeff Driskel | QB | 0% | 83% | 79% | 1% |
| Jerry Jeudy | WR | 75% | 57% | 73% | 69% |
| Melvin Gordon | RB | 63% | 79% | 62% | 80% |
| Royce Freeman | RB | 10% | 21% | 38% | 20% |
| Jake Butt | TE | 27% | 9% | 29% | 49% |
| Brett Rypien | QB | 0% | 0% | 21% | 99% |
| DaeSean Hamilton | WR | 80% | 44% | 19% | 81% |
| Andrew Beck | TE | 10% | 9% | 10% | 11% |
| Tyrie Cleveland | WR | 8% | 0% | 6% | 3% |
| Diontae Spencer | WR | 10% | 4% | 3% | 1% |
| Austin Schlottmann | G/C | 0% | 0% | 0% | 0% |
| Drew Lock | QB | 100% | 17% | 0% | 0% |
| Phillip Lindsay | RB | 32% | 0% | 0% | 0% |
| LeVante Bellamy | RB | 0% | 0% | 0% | 0% |
| Demar Dotson | T | 0% | 0% | 0% | 100% |
| Calvin Anderson | T | 0% | 0% | 0% | 0% |
| Nick Vannett | TE | 27% | 30% | 0% | 40% |
| Courtland Sutton | WR | 0% | 40% | 0% | 0% |
Jeff Driskel played one snap which was a designed run in the red zone.